Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Specialties, Oncology
Cover of the book Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319689296
Publisher: Springer International Publishing Publication: November 25, 2017
Imprint: Springer Language: English
Author:
ISBN: 9783319689296
Publisher: Springer International Publishing
Publication: November 25, 2017
Imprint: Springer
Language: English

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.

Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.

Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

More books from Springer International Publishing

Cover of the book Intelligent Distributed Computing XI by
Cover of the book Teacher Development in Technology-Enhanced Language Teaching by
Cover of the book GeNeDis 2016 by
Cover of the book Distal Radius Fractures by
Cover of the book Uber by
Cover of the book The Phenomenological Critique of Mathematisation and the Question of Responsibility by
Cover of the book Nanocomposites, Nanophotonics, Nanobiotechnology, and Applications by
Cover of the book Norman Kings of Sicily and the Rise of the Anti-Islamic Critique by
Cover of the book Mutual Sustainability of Tubewell Farming and Aquifers by
Cover of the book Pitfalls in Musculoskeletal Radiology by
Cover of the book Astrophysics of Exoplanetary Atmospheres by
Cover of the book Local Treatment of Inflammatory Joint Diseases by
Cover of the book Supply Chain Segmentation by
Cover of the book Perspectives on Political Communication in Africa by
Cover of the book Modern Aspects of Josephson Dynamics and Superconductivity Electronics by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy