EGF Receptor in Tumor Growth and Progression

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Medical Science, Pharmacology
Cover of the book EGF Receptor in Tumor Growth and Progression by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783662033913
Publisher: Springer Berlin Heidelberg Publication: April 17, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783662033913
Publisher: Springer Berlin Heidelberg
Publication: April 17, 2013
Imprint: Springer
Language: English

The last 15 years have brought an understanding of growth and differentiation at the molecular level, expanding our knowledge of the origin and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal. Oncogenes with diverse growth-promoting activities have been discovered, covering the gamut from cell surface to nuclear signaling. Sequencing of these oncogenes revealed that they were mutated forms of captured cellular genes and displayed tyrosine kinase activity. The epidermal growth factor (EGF) receptor was the first of 40-50 transmembrane tyrosine kinase receptors to be cloned and sequenced. Beyond cell proliferation, activation of EGF receptor by its specific ligands controls important physiological processes, such as cell differentiation, apoptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The last 15 years have brought an understanding of growth and differentiation at the molecular level, expanding our knowledge of the origin and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal. Oncogenes with diverse growth-promoting activities have been discovered, covering the gamut from cell surface to nuclear signaling. Sequencing of these oncogenes revealed that they were mutated forms of captured cellular genes and displayed tyrosine kinase activity. The epidermal growth factor (EGF) receptor was the first of 40-50 transmembrane tyrosine kinase receptors to be cloned and sequenced. Beyond cell proliferation, activation of EGF receptor by its specific ligands controls important physiological processes, such as cell differentiation, apoptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.

More books from Springer Berlin Heidelberg

Cover of the book Arthritis by
Cover of the book Sprachverarbeitung und Sprachübertragung by
Cover of the book The Technology of Binaural Listening by
Cover of the book Penetrating Trauma by
Cover of the book Quantile Regression for Spatial Data by
Cover of the book Solar Ultraviolet Radiation by
Cover of the book Handbook on Business Process Management 2 by
Cover of the book Hydroformylation for Organic Synthesis by
Cover of the book Microsurgical Brain Aneurysms by
Cover of the book Psychoanalysis and the Concept of a Rule by
Cover of the book Positive Linear Maps of Operator Algebras by
Cover of the book Scientists in Search of Their Conscience by
Cover of the book Pancreatic Disease by
Cover of the book Erdmessung und Satellitengeodäsie by
Cover of the book Transactions of the 8th Annual Meeting of the European Club for Ophthalmic Fine Structure in West Berlin, March 28 and 29,1980 by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy