Crystallization of Membrane Proteins

Nonfiction, Health & Well Being, Medical, Alternative & Holistic Medicine, Alternative Medicine
Cover of the book Crystallization of Membrane Proteins by Hartmut Michel, CRC Press
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Author: Hartmut Michel ISBN: 9781351088176
Publisher: CRC Press Publication: January 18, 2018
Imprint: CRC Press Language: English
Author: Hartmut Michel
ISBN: 9781351088176
Publisher: CRC Press
Publication: January 18, 2018
Imprint: CRC Press
Language: English

The precise knowledge of the structure of biological macromolecules forms the basis of understanding their function and their mechanism of action. It also lays the foundation for rational protein and drug design. The only method to obtain this knowledge is still crystallography. At present, the structures of about 400 proteins are known at or nearly at atomic proteins. However, only two of them are membrane proteins or complexes of the membrane proteins. The reasons for the difference is not the crystals of membrane proteins resists forming special problems when being analysed. The reason is that the membrane proteins resist into forming into well-ordered crystals. The intention of this book is to help to produce well-ordered crystals proteins and to provide guidelines, it is aimed at both biochemists and protein crystallographer�s.

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The precise knowledge of the structure of biological macromolecules forms the basis of understanding their function and their mechanism of action. It also lays the foundation for rational protein and drug design. The only method to obtain this knowledge is still crystallography. At present, the structures of about 400 proteins are known at or nearly at atomic proteins. However, only two of them are membrane proteins or complexes of the membrane proteins. The reasons for the difference is not the crystals of membrane proteins resists forming special problems when being analysed. The reason is that the membrane proteins resist into forming into well-ordered crystals. The intention of this book is to help to produce well-ordered crystals proteins and to provide guidelines, it is aimed at both biochemists and protein crystallographer�s.

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