Concepts and Models for Drug Permeability Studies

Cell and Tissue based In Vitro Culture Models

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology
Cover of the book Concepts and Models for Drug Permeability Studies by Bruno Sarmento, Elsevier Science
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Author: Bruno Sarmento ISBN: 9780081001141
Publisher: Elsevier Science Publication: September 30, 2015
Imprint: Woodhead Publishing Language: English
Author: Bruno Sarmento
ISBN: 9780081001141
Publisher: Elsevier Science
Publication: September 30, 2015
Imprint: Woodhead Publishing
Language: English

This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.

  • Updated information regarding the most recent in vitro models to study the permeability of drugs
  • Short and concise chapters covering all the biological barriers with interest in drug permeability
  • A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models
  • Simple and clear scientific content, adaptable for young scientists and experimented researchers
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This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.

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