Cellular Therapy of Cancer

Development of Gene Therapy Based Approaches

Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.

Contents:

• Challenges of T-Cell Therapy (Naomi Taylor, Anna Mondino and Balbino Alarcon)
• Gene Transfer into T Cells (David Gilham and Hinrich Abken)
• TCR-Engineered T Cells (Reno Debets and Ton Schumacher)
• T-Bodies: Antibody-Based Engineered T-Cell Receptors (John Bridgeman, Andreas A Hombach, David Gilham, Zelig Eshhar and Hinrich Abken)
• T-Cell Engineering and Expansion — GMP Issues (Cor Lamers and Ryan Guest)
• Clinical Trial Design (Robert Hawkins, John Haanen and Fiona Thistlethwaite)

Readership: Cancer researchers, oncologists and healthcare professionals.
Key Features:

• The authors include many of Europe's leading scientists in the field, all of whom contribute to a leading, highly rated, EC funded consortium
• It includes up-to-date results from all aspects of cancer research from basic research to clinical data
• The therapies being developed within this research field have the potential to significantly improve the treatment of many hard to treat cancers and therefore represent a significant step forward in cancer research