Cells, Aging, and Human Disease

Nonfiction, Health & Well Being, Medical, Specialties, Geriatrics, Science & Nature, Science, Biological Sciences, Cytology
Cover of the book Cells, Aging, and Human Disease by Michael B. Fossel, M.D., Oxford University Press
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Michael B. Fossel, M.D. ISBN: 9780190286262
Publisher: Oxford University Press Publication: June 10, 2004
Imprint: Oxford University Press Language: English
Author: Michael B. Fossel, M.D.
ISBN: 9780190286262
Publisher: Oxford University Press
Publication: June 10, 2004
Imprint: Oxford University Press
Language: English

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

More books from Oxford University Press

Cover of the book USMLE Step 2 Triage by Michael B. Fossel, M.D.
Cover of the book Moral Minorities and the Making of American Democracy by Michael B. Fossel, M.D.
Cover of the book Los contratos civiles by Michael B. Fossel, M.D.
Cover of the book We'll Have Manhattan by Michael B. Fossel, M.D.
Cover of the book The Risk of a Lifetime by Michael B. Fossel, M.D.
Cover of the book Interrogating Ethnography by Michael B. Fossel, M.D.
Cover of the book Dirty Love by Michael B. Fossel, M.D.
Cover of the book Caliph and Caliphate: Oxford Bibliographies Online Research Guide by Michael B. Fossel, M.D.
Cover of the book The Revelations of St. Birgitta of Sweden by Michael B. Fossel, M.D.
Cover of the book The People's Artist by Michael B. Fossel, M.D.
Cover of the book Unequal Justice by Michael B. Fossel, M.D.
Cover of the book Pediatric Palliative Care by Michael B. Fossel, M.D.
Cover of the book A New Engagement? by Michael B. Fossel, M.D.
Cover of the book The Futility of Law and Development by Michael B. Fossel, M.D.
Cover of the book Max/MSP/Jitter for Music : A Practical Guide to Developing Interactive Music Systems for Education and More by Michael B. Fossel, M.D.
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy