BRAF Targets in Melanoma

Biological Mechanisms, Resistance, and Drug Discovery

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book BRAF Targets in Melanoma by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781493921430
Publisher: Springer New York Publication: November 24, 2014
Imprint: Humana Language: English
Author:
ISBN: 9781493921430
Publisher: Springer New York
Publication: November 24, 2014
Imprint: Humana
Language: English

​This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

​This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

More books from Springer New York

Cover of the book Old Growth Urban Forests by
Cover of the book Sensors and Microsystems by
Cover of the book Fundamentals of Space Business and Economics by
Cover of the book Principles and Practice of Stereotactic Radiosurgery by
Cover of the book Bergey's Manual of Systematic Bacteriology by
Cover of the book Innovative Management in Information and Production by
Cover of the book Multi-Modality Atherosclerosis Imaging and Diagnosis by
Cover of the book Sports Injuries of the Ankle and Foot by
Cover of the book Neurosurgical Management of Pain by
Cover of the book Climate Change Modeling Methodology by
Cover of the book Atlas of Ultrasound-Guided Procedures in Interventional Pain Management by
Cover of the book Ordering Block Designs by
Cover of the book Essentials of Food Science by
Cover of the book Resilience in Children, Adolescents, and Adults by
Cover of the book Residue Reviews / Rückstands-Berichte by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy