Biomolecular Forms and Functions

A Celebration of 50 Years of the Ramachandran Map

Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.

Contents:

• The Legacy of G N Ramachandran and the Development of Structural Biology in India (M Vijayan)
• The Open-Ended Intellectual Legacy of GNR (George Rose)
• The Ramachandran Plot and Protein Structure Validation (Roman A Laskowski, Nicholas Furnham and Janet M Thornton)
• Analysis of Dihedral Angle Variability in Related Protein Structures (Shekhar C Mande, Ashwani Kumar and Payel Ghosh)
• Multiprotein Assemblies: Modulating Cell Activity Through Targeting Protein-Protein Interfaces (Alicia P Higueruelo, Harry Jubb and Tom L Blundell)
• Computational Approaches for Understanding the Recognition Mechanism of Protein Complexes (M Michael Gromiha)
• Cold-Shock Domains — Versatile Molecular Modules for Single-Stranded RNA Binding and Remodeling (Florian Mayr and Udo Heinemann)
• Protein Disulfide Analysis and Design (Siddharth Patel, S Indu, C Ramakrishnan and Raghavan Varadarajan)
• Controlling Conformational Dynamics to Modulate Protein Function (Shahir S Rizk, Marcin Paduch and Anthony A Kossiakoff)
• Structural Bioinformatics Approaches for Deciphering Biosynthetic Code of Secondary Metabolites (Shradha Khater and Debasisa Mohanty)
• The Inherent Structure Landscape of Met–Enkephalin Determined by the MOLS Technique (N Balaji, L Ramya and N Gautham)
• and other papers

Readership: Practicing researchers in academia and industry.
Key Features:

• Authors are eminent scientists with well-cited research in structural and computational biology
• The book includes articles covering results obtained using the latest structural biology techniques
• The book covers important areas in the fields of protein folding, association, function and design