Bioisosteres in Medicinal Chemistry

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Bioisosteres in Medicinal Chemistry by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Wiley
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ISBN: 9783527654321
Publisher: Wiley Publication: June 18, 2012
Imprint: Wiley-VCH Language: English
Author: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
ISBN: 9783527654321
Publisher: Wiley
Publication: June 18, 2012
Imprint: Wiley-VCH
Language: English

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

More books from Wiley

Cover of the book Umweltchemie by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Wiley Series 9 Securities Licensing Exam Review 2019 + Test Bank by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Micro and Nano Scale NMR by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Evil Online by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Time-Frequency Analysis by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book The Trainer's Handbook by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Breakthrough Nonprofit Branding by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Processing, Properties, and Design of Advanced Ceramics and Composites II by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Candlestick and Pivot Point Trading Triggers by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Handbook of Industrial Inkjet Printing by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Characterization Techniques for Polymer Nanocomposites by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Air Travel and Health by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Sedimentary Petrology by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Public Health Law Research by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Statistical Distributions by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy