Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neurology, Science & Nature, Science, Biological Sciences
Cover of the book Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors by Erkki Nissinen, Elsevier Science
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Author: Erkki Nissinen ISBN: 9780123813275
Publisher: Elsevier Science Publication: November 20, 2010
Imprint: Academic Press Language: English
Author: Erkki Nissinen
ISBN: 9780123813275
Publisher: Elsevier Science
Publication: November 20, 2010
Imprint: Academic Press
Language: English

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

  • Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
  • Preclinical models in COMT inhibitor devlopment
  • Transgenic COMT mice – latest information summarized
  • Chemistry of COMT inhibitors and their design with molecular modelling
  • COMT gene and its regulation and relation to dopamine related diseases
  • Role of cofactor SAM regulation in relation to homocysteine
  • Nonclinical and clinical safety of COMT inhibitors summarized
  • Future prospects of COMT inhibitors in Parkinson’s disease
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

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