Antibody Fc

Linking Adaptive and Innate Immunity

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Ailments & Diseases, Infectious Diseases, General
Cover of the book Antibody Fc by , Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9780123948182
Publisher: Elsevier Science Publication: August 6, 2013
Imprint: Academic Press Language: English
Author:
ISBN: 9780123948182
Publisher: Elsevier Science
Publication: August 6, 2013
Imprint: Academic Press
Language: English

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

  • Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro
  • Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies
  • Color illustrations enhance explanations of the immune system
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

More books from Elsevier Science

Cover of the book Stress Science by
Cover of the book Alternative and Replacement Foods by
Cover of the book Climate Change by
Cover of the book RAPID Value Management for the Business Cost of Ownership by
Cover of the book Sorting and Recycling Endosomes by
Cover of the book Corporate Security Management by
Cover of the book Dynamics of Thin Walled Elastic Bodies by
Cover of the book Estuaries by
Cover of the book Bone Substitute Biomaterials by
Cover of the book Preserving Electronic Evidence for Trial by
Cover of the book The Cytokine Handbook, Two-Volume Set by
Cover of the book Practical Business Statistics by
Cover of the book Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by
Cover of the book The Effect of Creep and other Time Related Factors on Plastics and Elastomers by
Cover of the book Contagion Phenomena with Applications in Finance by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy