ABC Transporters - 40 Years on

Nonfiction, Science & Nature, Science, Biological Sciences, Biophysics, Cytology
Cover of the book ABC Transporters - 40 Years on by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319234762
Publisher: Springer International Publishing Publication: December 16, 2015
Imprint: Springer Language: English
Author:
ISBN: 9783319234762
Publisher: Springer International Publishing
Publication: December 16, 2015
Imprint: Springer
Language: English

This book provides new structural, biochemical, and clinical information on ABC transporters.  The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book provides new structural, biochemical, and clinical information on ABC transporters.  The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders

More books from Springer International Publishing

Cover of the book Quantum Radiation in Ultra-Intense Laser Pulses by
Cover of the book Algebraic Combinatorics by
Cover of the book Information Theory and Coding - Solved Problems by
Cover of the book Mapping Biological Systems to Network Systems by
Cover of the book Systems Biology by
Cover of the book Interfirm Networks by
Cover of the book Business Information Systems by
Cover of the book Evacuation Modeling Trends by
Cover of the book Human Interface and the Management of Information. Information and Knowledge Design by
Cover of the book Pediatric Radiation Oncology by
Cover of the book Hemodynamic Monitoring in the ICU by
Cover of the book International Medical Graduate Physicians by
Cover of the book Contact Mechanics of Articular Cartilage Layers by
Cover of the book Public Health Intelligence by
Cover of the book The Great War in Belgium and the Netherlands by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy