A Network-Based Approach to Cell Metabolism

From Structure to Flux Balances

Nonfiction, Science & Nature, Technology, Engineering, Chemical & Biochemical, Science, Biological Sciences
Cover of the book A Network-Based Approach to Cell Metabolism by Oriol Güell, Springer International Publishing
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Author: Oriol Güell ISBN: 9783319640006
Publisher: Springer International Publishing Publication: August 16, 2017
Imprint: Springer Language: English
Author: Oriol Güell
ISBN: 9783319640006
Publisher: Springer International Publishing
Publication: August 16, 2017
Imprint: Springer
Language: English

This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.

The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.

Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec

ts of the networks themselves to the balance of biochemical fluxes.

 

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This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.

The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.

Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec

ts of the networks themselves to the balance of biochemical fluxes.

 

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